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The Science of Aging Well

Research, insights, and practical advice for healthy aging through nutrition.

Omega-3 capsules beside a chart of blood omega-3 levels

October 9, 2026

The Omega-3 Index: The Blood Test Worth Knowing About

The average adult in the UK Biobank sits at about 5.6%. The proposed target is 8% or above. Here is what the Omega-3 Index measures, what the data behind that target can and cannot tell you, and what shifts your own result.

Close-up of a human eye, illustrating the tear film affected by dry eye disease

October 6, 2026

DHA and Dry Eye: The Ophthalmology Research

A landmark 535-patient trial found high-dose fish oil no better than an olive oil placebo for dry eye disease. The pooled data since then complicates that verdict, and the fraction that seems to matter most is not the one DHA-led products lead with.

An NMN capsule on a plain surface, representing the gap between supplement marketing and trial data

September 20, 2026

NMN and Blood Sugar: What Glucose Metabolism Studies Show

Fifteen randomised trials, 383 adults, and a fasting glucose shift of 0.04 mmol/L. One 25-person trial found something real in muscle. Here is why the two results do not contradict each other — and what moves the number instead.

The NAD+ molecule, and the smaller precursors that actually reach the cell

September 18, 2026

Why NAD+ Cannot Be Taken Directly as a Supplement

Eight men had 750 mg of NAD+ dripped straight into a vein over six hours. For the first two hours, none of it appeared in their blood. The molecule is too big and too charged to go anywhere intact, and that is before the gut gets involved.

Taking the stairs — light movement broken across a working day

September 17, 2026

NMN for Desk Workers: Sedentary Metabolism and NAD+

Two weeks of low stepping cost ten healthy men 17% of their insulin sensitivity. The enzyme that recycles your NAD+ is set by movement, not by capsules. Here is what NMN can and cannot do about a desk.

A plate of whole foods on a kitchen table, representing an eating window rather than a diet

September 10, 2026

Time-Restricted Eating: What the Human Trials Found

Across 116 adults randomised to a 16:8 window or three meals a day, the 12-week difference in weight was 0.26 kg. The interesting result is not the scale. It is what the DXA scans showed.

Supplement capsules beside printed research papers — judging a trial by its sample size

September 9, 2026

Why Most Supplement Studies Are Too Small to Trust

A trial of 20 people per arm has about a 16% chance of detecting a real, modest effect. It has a much better chance of producing a headline. Here is what sample size does to a result, and the four checks that tell you whether a study is worth your attention.

Mitochondria and the electron transport chain, where CoQ10 and NAD+ both work

September 8, 2026

NMN vs CoQ10 for Cellular Energy

A meta-analysis of 13 trials in 1,126 people found CoQ10 cut fatigue scores by about a third of a standard deviation. The pooled NMN evidence on physical performance is smaller, shorter and flatter. Here is what each one has actually shown.

Cholesterol blood testing and cardiovascular risk — comparing apolipoprotein B with LDL cholesterol

September 7, 2026

ApoB vs LDL-C: Which Cholesterol Number Matters More

Across 233,455 adults, apoB carried 43% more cardiovascular risk per standard deviation. LDL-C carried 25%. Where the two numbers disagree, who they mislead, and how to get apoB measured in the UK.

Comparing UK supplement labels and batch test certificates before buying

September 6, 2026

Buying Supplements in the UK: How to Spot a Legitimate Seller

Eighty-nine per cent of 57 sports supplements did not contain what their labels declared. UK law already asks a lot of a supplement seller. Here is what compliance looks like from the outside, and the checks that separate a real operation from a drop-shipper.

Omega-3 softgel capsules beside a glass of water

September 4, 2026

Heavy Metals in Fish Oil: What Testing Reveals

Across 1,894 commercial fish oils, mean mercury came in at 0.0005 mg/kg — one two-hundredth of the legal ceiling. The quality problem in this category is real, but it is not the metals.

Algae-derived omega-3 oil — working out a daily DHA dose

September 3, 2026

How Much DHA Do You Actually Need Per Day?

The authorised claim sits at 250 mg a day. The trials that moved muscle, triglycerides or blood levels used four to fourteen times that. Your body weight, the chemical form and the meal you take it with all change the number.

Omega-3 capsules alongside a chart of pooled effect sizes for mood

September 2, 2026

Omega-3 and Mood: Reviewing the Evidence Honestly

The largest randomised trial on this question gave 18,353 adults omega-3 for five years and came back flat. The small signal that does exist belongs to EPA, at a dose most capsules never reach.

Omega-3 capsules and a dose ladder for adults over 50

September 1, 2026

Omega-3 After 50: Priorities and Dosage

The biggest trial ever run in adults over 50 gave 840 mg a day for five years and missed its primary endpoint. The useful effects sit elsewhere — and at higher doses than most labels carry.

Morning and evening dosing schedules for NMN compared across a twelve-week trial

August 30, 2026

Morning vs Evening NMN: Does Timing Change the Result?

Take 250 mg of NMN after 6pm for twelve weeks and your sleep score falls 1.5 points. Take a placebo after 6pm and it falls 1.6. That is the whole timing literature, and it is worth reading properly.

Diagram of the NMN and NR routes into the cell and on to NAD+

August 29, 2026

NMN vs NR: Which NAD+ Precursor Reaches Your Cells?

Both molecules end up as the same thing inside the cell. The argument is about how they get in, and whether any of it reaches the tissue you care about. Here is what the human data shows.

Cyclist training in the gym, working on threshold and muscular endurance after 50

August 28, 2026

NMN for Cyclists: NAD+, VO2 Max and Recovery

One six-week trial in 48 amateur runners raised power at the ventilatory thresholds and left VO2 max untouched. Meanwhile, twelve weeks of training raised the NAD+ salvage enzyme by 28% on its own. Here is how a rider should read that.

Supplement capsules and research papers — reading the statistics behind a trial result

August 26, 2026

What a p-Value Actually Tells You About a Supplement Study

A p-value of 0.04 does not mean a 96% chance the supplement works. It answers a narrower question than almost anyone selling you something wants to admit. Here is what the number measures, what it hides, and the six questions worth asking instead.

Blood testing and cardiovascular risk — what a high-sensitivity CRP result means

August 24, 2026

hs-CRP: The Inflammation Marker Worth Tracking

A three-fold higher CRP came with 37% more coronary events across 160,309 adults. Then the genetics arrived and complicated it. What the marker is worth, how noisy it is, and what actually shifts it.

UK novel foods regulation and the Food Standards Agency register

August 22, 2026

Novel Foods in Great Britain: How the Regulation Works

The statute gives the risk assessor nine months. Across 292 dossiers, the average run from submission to published opinion was 935 days. Here is what the GB novel foods process does, and where NMN and algal DHA sit inside it.

Trans-resveratrol and cis-resveratrol isomers compared

August 21, 2026

Trans-Resveratrol vs Cis-Resveratrol: Why the Form Matters

Only seven of 20 resveratrol supplements named the isomer on the label. That word covers two molecules with different stability, different absorption and, on recent evidence, opposite effects on one repair pathway.

Closed algae cultivation vessels — how vegan DHA oil is fermented

August 20, 2026

Algae Oil: How Vegan DHA Is Actually Made

Vegan DHA does not come from seaweed or a pond. It is fermented in the dark, in stainless steel, on sugar. Here is the chain from seed flask to softgel, and the three numbers that tell you whether a given bottle was made well.

Omega-3 capsules — comparing DHA and EPA head to head

August 18, 2026

DHA vs EPA: What Each Omega-3 Does in Your Body

Nine trials have given people pure EPA or pure DHA and compared them directly. DHA wins on blood pressure and triglycerides, loses on LDL, and EPA holds the only large outcome trial. The gap matters more than the label suggests.

DHA and memory — what randomised trials in healthy adults reported

August 17, 2026

DHA and Memory: What the Trials in Healthy Adults Found

Two trials in over 5,000 adults found no cognitive effect at all. Three smaller ones found a memory benefit. The difference is not dose — it is who was enrolled, and that changes what the evidence is worth to you.

NMN supplement capsule with NAD+ molecule — the science behind NAD+ boosting

March 15, 2026

What Is NMN? The Science Behind NAD+ Boosting

Discover how Nicotinamide Mononucleotide works as a direct precursor to NAD+, why your levels decline with age, and what the latest research says about supplementation.

NMN and Resveratrol benefits for men over 50

April 4, 2026

NMN + Resveratrol for Men Over 50

How NMN and Resveratrol support cardiovascular health, energy, muscle preservation, and cognitive performance in men over 50 — backed by clinical evidence.

NMN and Resveratrol benefits for women over 40

April 4, 2026

NMN + Resveratrol for Women Over 40

Energy, skin health, hair, and healthy ageing through menopause and beyond — how this science-backed combination supports women's health after 40.

Vegan omega-3 UK buyer's guide 2026 — algae DHA supplements

April 4, 2026

Vegan Omega-3 UK Buyer's Guide 2026

Everything you need to know about choosing a high-quality vegan omega-3 supplement in the UK — dosage, DHA vs EPA, algae sources, and what to avoid.